Primaliv Tablet

Causes of liver diseases according to Ayurveda

According to ancient Ayurvedic Science imbalance of tridosha (body humors) are the main cause of diseased state. Ayurveda describes the liver as a fiery, hot organ and this is due to presence of Agni and pitta in the liver. Here, Agni is correlated to metabolic fire whereas pitta is correlated to Bile. The imbalance of pitta dosha and agni results in increased waste products or toxins and cell damage. This gives rise to udarroga (Udar is area where almost all organs especially related to digestion resides and Roga means disease). If pitta dosh imbalance continues for a longer duration, serious liver disorders like jaundice, hepatitis, cirrhosis and cancer may develop.

Reasons of Pitta imbalance:

The imbalance of tridosha can happen by dietary indiscrimination like eating pitta aggravating foods such as junk food and processed food items, alcohol abuse, stress and lack of sleep etc. Change in season and improper exercise can also result in imbalance of tridosha. Finally, this imbalance of dosha will result in Non- alcoholic fatty liver disease (NAFLD), Alcohol related liver disease, hepatitis, jaundice, cirrhosis and even death if not treated in time. Pitta imbalances are classically hot and inflammatory in nature that’s why its equilibrium should be maintained to avoid any damage to the liver.

Junk food or processed food contains refined sugars and trans-fats which can cause a fatty build up in the liver. Packed foods and baked goods contain high trans-fat and sugars that make you more likely to gain weight. Even if you are not overweight but you are taking junk food on regular basis, there are high chances of development of fatty liver disease.

The over use of refined sugars and trans-fats results in accumulation of excessive fat in liver cells (hepatocytes) which further leads to a condition fatty liver. The harmful effect of fast food on the body is also related to the formation of free radicals. Free radicals can cause damage to cells in the body by reacting with molecules in cell.

Similarly, the persons which are physically inactive but are on high calorie diet have increased incidence of liver disease. Moderate exercise is a healthy practice. However, exhaustive exercise generates free radicals leading to liver damage.

When liver is rapidly abused and not given a chance to recover then the damage become irreversible and progressive. So, the safeguard against liver disease is to prevent further liver damage by opting Hepatoprotectives and hepatostimulants.

Composition

Each tablet contains

Mass extract of:

Bhringraj 400mg, Punarnava450mg, Mulethi 250mg, Bhumiamlaki 550mg, Chitrak 500mg, Kalmegh200mg, Haridra 200mg, Guduchi 250mg

Powders of: Kutki 100mg, Milk Thistle extract 45mg, Kalmegh 85mg, Pippali20mg

Liquid: Shudhashilajit 28mg

Features of Herbs

Bhringraj(Ecliptaalba):

Bhringraj helps in detoxification of Liver and works as hepatic stimulant. It has Katu (pungent) and Tikta (bitter) taste. It improves overall liver health.

The components of E.alba like wedelo-lactone, demethyl-wedelolactone and saponins reduced fat deposition, mononuclear infiltration, and necrotic foci, and stimulated liver cell regeneration.

Punarnava(Boerhaviadiffusa):

In Ayurveda, Punarnava is known to be used as Sothaghna (anti-inflammatory), and Rasayana (rejuvenator). It has a pittahar action. It also has proved studies which show hepatoprotective action of Punarnava. The studies have shown the following positive responses in the treatment of liver diseases-

• Elevation in the decreased levels of antioxidant
• Elevated levels of liver marker enzymes.

Bhumiamlaki(Phyllanthusniruri):

In Ayurvedic literature, Bhumiamlaki is known to be used as Kaphapittahara (which relieves the Kapha Pitta dosha), Kaamalahar (Which cures jaundice). Bhumiamla provides synergetic effect when given with Silymarin. It provides hepatoprotective action as it normalizes ROS (Reactive oxygen species) by their high antioxidant content and attenuating endogenous antioxidant enzymes to their normal level and stimulates the liver repair mechanism.

Chitrakmool(Plumbagozeylanica):

Chitrakmool has bitter taste therefore it is beneficial in liver problems. It helps in proper functioning of the liver. Several phytoconstituents viz., tri-terpenes, sterols, zeylonone of Plumbagozeylanica have been found effective in the hepato-protection against paracetamol induced hepatic toxicity. Administration of P. zeylanica decreased the level of bilirubin and increased the level of protein suggesting that it offered protection.

• It also significantly decreased serum lipid profile in paracetamol toxicity induced rats because of its hypolipidemic effects and supplementation enhanced esterification effect through hepato-protective property by inhibiting the free radicals effect on livercells.
• γ‐glutamyltransferase (GGT) level were maintained by Plumbagozeylanica treatment due to its antioxidant activity.
• Treatment with P. zeylanica decreased the serum levels of SGOT and SGPT towards the respective normal value that is an indication of stabilization of plasma membrane as well as repair of hepatic tissue.

Kutki(PicrorhizaKurroa):

It is an established herbal remedy for variety of disease ranging from indigestion to hepatitis. Modern clinical studies have confirmed the efficacy and safety of Picrorhizakurroa for the treatment of liver disease. Pharmacologically, Kutkin (Picrosides and kutkosides) has hepatoproptective activity. The therapeutic activity of the drug may be based on two mechanisms:

• Kutkins alter the structure of the outer membrane of the hepatocytes in such a way as to prevent penetration of the liver toxin into the interior of the cell.
• Kutkins stimulate the action of nucleolar polymerase A, resulting in ribosomal protein synthesis and, thus stimulates the regenerative ability of the liver and formation of new hepatocytes.
• Apocynin, is one of its constituents, has been found to exhibit powerful anti- inflammatory effects on a variety of inflammatory models.

 

Pippali(Piper longum):

Pippali is one of the potent herbal drugs which can improve the regeneration process by restricting fibrosis and having hepatoprotective action. It contains various alkaloids like piperine, piperlongumine, piperlonguminine, etc. which helps in the regeneration of hepatocytes. Additionally, it acts as bioavailability enhancer.

• Various studies have shown that treatment with the ethanolic extract of longum inhibits liver fibrosis induced by carbon tetrachloride (CCl₄).
• An evident decrease in the level of serum enzymes, total bilirubin, and direct bilirubin was also observed.

Milk Thistle(Silybummarianum):

It is arguably the most commonly used medication for various liver diseases. It is a mixture of flavonolignans (isosilybinA, isosilybin B, silybin A, Silybin B, isosilychristin, silychristin and silydianin) and a flavonoid (taxifolin).

It act as a hepatoprotective by-

• Exerting membrane stabilizing and antioxidant activity.
• Promotes hepatocyte regeneration
• Reduces inflammatory reactions
• Inhibits fibrogenesis in liver
• Increase protein synthesis in hepatocytes by stimulating RNA polymerase activity.

Kalmegh(Andrographispaniculata):

Kalmegh has wide range of medicinal values. It is utilized in various liver problems due to its tikta rasa.In a study, the hepatoprotective activity of methanolic extracts of Andrographispaniculata was evaluated against paracetamolliver damage. The results of the study indicated that the extract exhibits significant protective effect in the liver morphology.^{Sutha, Devaraj et al./J Phytol 2/11 (2010) 25-30}

Guduchi(Tinosporacordifolia):

Guduchi has tridoshashamak properties. Therefore, it helps in balancing of the tridosha (Vata, Pitta &kapha). It is a rasayana herb that also supports immunity and overall health of a person. In a study, the hepatoprotective activity of T. cordifolia was evaluated forCCl₄ induced hepatotoxicity in which it helps in normalizing the increased levels of liver enzymes and therefore, helps in liver dysfunction.^{Asian Journal of Pharmaceutical and Clinical Research 2013. 6(1):87-91}

Haridra(Curcuma longa):

Haridra has katutikta rasa due to which it supports liver functioning. The hepatoprotective effects of Curcuma longa Rhizome extract(CLRE) on the development of liver cirrhosis, induced by prolonged exposure to thioacetamide (TAA) were assessed though theexperimental study.Results concluded that the plant natural extract exerted its hepatoprotective effect by preventing the harmful effects of TAA toxicity.This hepatoprotective capability of CLRE preserved the liver’s status quo in terms of its properties, functions and structure against toxins.^{Salama et al. BMC Complementary and Alternative Medicine 2013, 13:56}

Mulethi(Glycyrrhizaglabra):

Mulethi supports the liver health. In a study, the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl₄) induced liver injury in a rat model was evaluated. Licorice extract significantly inhibited the increase of liver enzymes that were responsible for liver damage.^{Int. J. Mol. Sci. 2011, 12, 6529-6543}

Shilajit:

Shilajit is an important, known component of the ayurvedic medicine given its characteristics as a rasayana. In this context, health benefits such as an increase in longevity rejuvenating, and arresting aging roles have been attributed to it. It is used as yogavaha, that is, as synergistic enhancer of other drugs. Organic components of shilajit play also a role in transporting different mineral substances to their cellular targets^{.International Journal of Alzheimer’s Disease Volume 2012, Article ID 674142, 4 pages}

Justification and Rationale of the Combination

Liver is the organ that helps in number of functions such as detoxification, synthesis of proteins and production of biochemicals important for digestion and growth of an individual. Liver dysfunction also affects the functioning of other organs such as Kidneys and various metabolic processes like digestion; detoxification etc.

PRIMALIV is the unique formulation along with Milk thistle extract along with other potent herbsthat offers multiple benefits like hepatoprotective, hepatostimulant, and antioxidant.

• Milk Thistle (Silymarin) in Primaliv exerts membrane stabilizing activity and prevents fibrogenesis in liver. It also promotes regeneration of hepatocytes and stimulates RNA polymerase activity to increase protein synthesis in hepatocytes.
• Punarnava,Chitrak, Bhringraj and Bhumiamlaki prevent loss of functional integrity of cell membrane and restore the normal balance of hepatic enzymes.
• Pippali improves the regeneration process of hepatocytes by restricting fibrosis whereas Kutaki prevents penetration of toxins inside the cell and stimulates regeneration of cells.
• Mulethi, Haridra, Guduchi and Kalmegh act as a Hepatoprotective and protect the liver from damage from the byproducts of various chemical moieties.

Primalivtablets hastens recovery period & ensure early restoration of hepatic functions in infective hepatitis. It can be prescribed to treat various liver conditions like early liver cirrhosis, fatty liver, jaundice and anorexia. It is also a logical adjuvant to various treatments like chemotherapy, Haemodialysis and anti-TB treatment. It has pitta balancing properties by which it balances the vitiated pitta Dosha. Thus, counteracts the root cause of liver problems, and improves liver function.