Insormac h Tablet

Transient Insomnia – Lasting from a night to a week and is usually caused by events which alters normal sleep pattern, such as traveling or sleeping in an unusual environment.

Acute insomnia -Acute insomnia lasts for less than three months. It is also called Short-term insomnia.

Chronic insomnia lasts for at least three months or longer and is usually secondary to another problem or a combination of problems.

SYMPTOMS OF INSOMNIA

People who experience insomnia usually report at least one of these symptoms:

• Waking too early in the morning
• Trouble falling asleep
• Waking up during the night
• Not feeling well-rested after a night’s sleep
• Daytime tiredness or sleepiness
• Irritability, depression or anxiety
• Difficulty in paying attention, focusing on tasks or remembering
• Increased errors or accidents
• Ongoing worries about sleep

Insomnia according to ayurveda

According to Ayurveda, Aahara (food), Nidra (Sleep) and Bramhacharya (Abstinence) are described to be the Trayopasthambas(Three supportive pillars). Proper sleep plays an important role in maintaining health, proficiencyand emotional well-being. Hence forth, Sleep is one of the essential factors to lead a healthy life.

In Ayurveda, Insomnia is known as Anidra or Nindranasha. According to Ayurveda, the vitiation of the three doshas either taken all together or individually may result in to insomnia.

Kapha nourishes the brain cells and facilitates a good night’s sleep. Imbalance of this dosha causes poor nourishment of brain cells, leading to Insomnia.

Pitta is located in the heart. It controls emotions, desires, decisiveness, and spirituality. Its imbalance makes a person demanding and workaholic, thereby leading to situations that may cause lack of sleep.

Vata is linked to insomnia, worry, anxiety, and problems like depression and causes insomnia.

In each patient, different combinations of doshas can lead to the disease. The Ayurvedic treatment of Insomnia focuses on balancing the aggravated body energies through herbal medicines.In Ayurveda,treatment of insomnia has two goals. One is to help with quality and quantity of sleep. Second is to address the underlying cause and prevent long term health impacts due to it. Mano nivṛtti, a relaxed state of mind is also very much important for a sound sleep to get ensued.Medhyarasayan drugs are the specific types of drugs that are effective in treating insomnia, restlessness, and anxiety etc.

Composition

Each tablet contains

Aqueous extract derived from: Mandukparni 650mg, Kushmand 350 mg, Ashwagandha350mg,  Amla 200mg, Sarpagandha 200mg, Ustakhadus 200mg

Powders of: Jatamamsi 75mg, Ustakhadus 50mg, Sugandhbala 50mg

Features of Herbs

Mandukparni(Centellaasiatica)

In ayurveda it is described under the Medhyarasayana drugs. It has adaptogen, CNS relaxant and sedative action. It reduces tension, stress, anxiety and sleeplessness due to its sedative, tranquilizing and relaxant activity.

 Kushmand(Benincasahispida)

Kushmanda is one of the MedhyaRasayana.In some studies,extract of Benincasahispida fruit has been demonstrated to possess nootropic, antidepressant and anxiolytic like effect, which suggests that Benincasahispida influences various neurotransmitter systems including serotonergic system.

Ashwagandha(Withaniasomnifera)

It is considered as nervine tonic which is helpful in problems like anxiety, depression and insomnia etc.Research conducted at the Department of Pharmacology; University of Texas Health Science Center indicated that extracts of Ashwagandha produce GABA-like activity, owing to its anxiolytic effect.

In another study, the antistress activity of W. somnifera on cold swimming stress was evaluated and the results indicate a significant increase in the plasma corticosterone level, phagocytic index and avidity index in rats subjected to cold swimming stress. In the rats pretreated with the drug, these parameters were near control values and an increase in the total swimming time was observed W. somnifera is a potent antistressor agent in the crude form.^{Journal of Ethnopharmacology 64 (1999) 91–93}

 Amla(Emblicaofficinalis)

In Ayurveda, amla is well known rasayana drug and it is also known to cure insomnia.Ethanolic extract of fruits of Emblicaofficinalis was investigated on acute anoxia stress tolerance test in Swiss mice. The results indicate that extract of Emblicaofficinalis has significant Adaptogenic activity against variety of biochemical and physiological perturbations.^{Int. J. of Res. in Pharmacology &Pharmacotherapeutics Vol-3(1) 2014 [72-79]}

 Sarpgandha(Rauwolfiaserpentine)

Sarpagandha has Nidrajanaka Karma. Research works done on Sarpagandha shows that it is hypnotic, sedative, hypotensive, and CNS depressant in action.

A Study was conducted on 30 patients of Nidranasha (primary Insomnia) who fell under inclusion criteria. Sarpagandha tablets were prepared by givingBhavana of SarpagandhaMoolaKashaya (root decoction) and were given to patients for the duration of one month. Highly significant improvements were observed in chief complaints like sleep initiation, maintaining sleep, early morning awakening. ^{Jour. of Ayurveda & Holistic Medicine; Volume-III, Issue-IV: 30-41.}

Ustakhadus(Lavandulastoechas)

Ustakhadus helps to diminish Kapha and Vatadoshas. Results of several studies support its efficacy as a relaxant. Researchers tested the sedative properties of lavender essential oil and its main constituents, linalool and linalyl acetate.^{Lavandulastoechas L.A Guide to Medicinal Plants in North Africa, p- 171-173.}

 Jatamansi(Nardostachysjatamansi)

Jatamansi has tridosha balancing properties and exerts calming effect and improves quality of sleep and reduces sleeplessness. Studies suggest that this herb acts as a powerful antidote for sleeplessness and helps enhance the quality of sleep.In a study, the effectiveness of sedative and anxiolytic effect of N. jatamansi in compraison with diazepam.Obtained results indicated that extract of N. jatamansi gives sedative and anxiolytic effects.^{J. Med. Plants 2010, 4(36): 169-174}

Another study was undertaken to evaluate the antidepressant activity of methanolic extract of Nardostachysjatamansi. The efficacy of the extract was compared with the standard drug imipramine on normal and sleep deprived mice. Finding suggests that extract of Jatamansi has dose dependent antidepressant activity and can also be used in patients suffering from depression due to sleep disturbances. ^{Der Pharmacia Lettre, 2010, 2(5): 441-449}

 Sugandhbala(Valerianawallichii)and Jatamansi(Nardostachysjatamansi)

A clinical study was conducted to evaluate the effect of Tagara/Sugandhbala) and Jatamansi in the management of Anidra.A total of 34 patients were selected fulfilling the criteria for inclusions for primary insomnia were randomly selected from Out Patient Department and In Patient Department of ManasaRoga.In this clinical study, both the groups showed good results, but Tagara group showed better results in comparison to Jatamansi group.^{Ayu. 2015 Jan-Mar; 36(1): 46–49.}

 jatamansi (Tagar) is reported to be effective in treating various sleeping disorders in human. Clinical trials on V. jatamansi have confirmed that root extract reduces sleep latencyand improves sleep quality and therefore, considered useful in treating anxiety and insomnia.Many more studies have shown proven sedative effect of Tagar.^{Phytotherapy Research. 2019;1–22.}

Justification and Rationale of the Combination

Insomnia is a sleep disorder in which a person has trouble falling and/or staying asleep. According to Ayurveda, insomnia or Anidra occur due to imbalance of tridoshas (Vata, Pitta and Kapha). Imbalanced tridosha are the main causative factors of Anidra.

Insormac-H tablet is the herbal formulation which is effective in treating varioussleeping disorders. The ingredients of Insormac-H tablets are tridoshar in nature that helps in balancing the vitiated doshas and restoration of normal sleep cycle. Insormac-H is formulated by the combination of Ayurvedicrasayana herbs which also has tranquilizer, anti-depressant and anxiolyticproperties that helps to overcome insomnia caused due to stress or anxiety.

• Sarpagandha, Jatamansi, Sugandhabalaare sedative in nature and CNS depressants.
• The anti-stressor agents like Ustakadhus, Ashwagandha and Amlaare effective in relieving stress and restlessness and helps in providing good sleep.
• Insormac-H contains Medhyarasayan herbs like Mandukparni, Kushmanda, which will also provide strength to the brain & relieves mental fatigue.
• Insormac-H does not cause excessive sedation. Therefore, daily activities will not be hampered.